![]() Hydrocarbons of significantly higher molecular weight have correspondingly higher Hexane is extremely flammable (NFPA rating = 3), and its vapor can travel aĬonsiderable distance to an ignition source and "flash back." Hexane vapor formsĮxplosive mixtures with air at concentrations of 1.1 to 7.5 % (by volume). Inhalation of n-hexane vapors have shownreproductive effects in rats and mice. Occupational exposure to 500 ppmmay cause polyneuropathy (ACGIH 1986). Continuous exposure to 250 ppmn-hexane produced neurotoxic effects in animals. However, in the caseof hexane, the neurotoxic metabolite 2,5-hexanedione is produced to a much lesserextent. The neurotoxic metabolite, 2,5-hexanedione, however, is produced considerablyless in n-hexane. Thus methyl butylketone and n- hexane should have similartoxicities. The metabolites of n-hexane injected inguinea pigs were reported as 2,5- hexanedioneand 5-hydroxy-2-hexanone, which arealso metabolites of methyl butyl ketone(DiVincenzo et al. Chronicexposure to n-hexane may cause polyneuritis. In humans a 10-minute exposure toabout 5000 ppm may produce hallucination,distorted vision, headache, dizziness, nausea,and irritation of eyes and throat. Its acutetoxicity is greater than that of n-pentane.Exposure to a concentration of 40,000 ppmfor an hour caused convulsions and death inmice. N-Hexane is a respiratory tract irritant andat high concentrations a narcotic. Hexane will attack some forms of plastics, rubber and coatings. Hexane is also incompatible with dinitrogen tetraoxide. This would include compounds such as liquid chlorine, concentrated O2, sodium hypochlorite and calcium hypochlorite. Hexane can react vigorously with oxidizing materials. Hexane may also be sensitive to prolonged exposure to heat. Used as a solvent, paint thinner, and chemical reaction medium. Less dense than water and insoluble in water. General DescriptionĬlear colorless liquids with a petroleum-like odor. Suitable for HPLC, spectrophotometry, environmental testing DefinitionĬhEBI: An unbranched alkane containing six carbon atoms. Usesĭetermining refractive index of minerals filling for thermometers instead of mercury, usually with a blue or red dye extraction solvent for oilseed processing. It is usedas a solvent for adhesives, vegetable oils,and in organic analysis, and for denaturingalcohol. N-Hexane is a chief constituent of petroleumether, gasoline, and rubber solvent. An odor thresholdĬoncentration of 1.5 ppm v was reported by Nagata and Takeuchi (1990). Workers associated with long-term glue sniffi ng showed adverse effects in the form of degeneration of axons and nerve terminals.Ĭlear, colorless, very flammable liquid with a faint, gasoline-like odor. Occupational exposure of industrial workers has demonstrated motor polyneuropathy. It is highly toxic, triggering several adverse health effects, i.e., nausea, skin irritation, dizziness, numbness of limbs, CNS depression, vertigo, and respiratory tract irritation to animals and humans. N-Hexane is a highly flammable liquid, usually isolated from crude oil, and has extensive industrial applications as a solvent in adhesive bandage factories and other industries. Threshold is 0.0064 mg/L and the air/odor threshold isĢ30 875 milligram per cubic meter. Volatile liquid with a gasoline-like odor. N-Hexane is a highly flammable, colorless, Substances Added to Food (formerly EAFUS) Readily forms explosive mixtures with air. Incompatible with oxidizing agents, chlorine, fluorine, magnesium perchlorate. Very soluble in ethanol, ethyl ether and chloroform.
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